Kingpin
Wilson "Kingpin" Fisk became the Crime Lord of New York City by offing the Don Rigoletto. Commonly teased for his obesity, Fisk managed to make enemies of the Maggia and Hydra, as well as the odd super hero like spider man and Daredevil.
However, Fisk made a mistake of employing Kyle Tam as his assassin, or rather, of making him his assassin when Cassandra Cream had the same target. Tam's run-in with Cream had him nearly turned into breast fat, but she was able to get his employer's information from him through her powers. Single-handedly knocking out Fisk's bodyguards, Kingpin gets enraged when Cream teased him about his obesity. Without thinking, Fisk charges headlong into Cassandra, quickly being slurped up by her breasts. The fat man was now simply breast fat.